After living a "normal" life for 24 years, Delsin, who is a rebel Akomish Native American, discovers he is a Bioterrorist after touching one of them and acquiring the latter's powers. He is gifted with the ability to absorb any other Bioterrorist's power after touching them.
Delsin discovers his powers when he absorbs the abilities of Hank, a prisoner on a D.U.P. carrier, taking on Smoke Manipulation. Later, he discovers that he possesses the ability to mimic the powers of other Conduits.
Enhanced Strength: Like all Major Conduits, Delsin has enhanced strength. He effortlessly pulls his brother's arm off of Abigail Walker to the point where Reggie shows physical pain. He was also able to effortlessly pull off a chain link door off a cage.
Durability: Delsin is able to fall from relatively high distances and land unharmed.
Rapid Healing: Delsin is stated to be able to quickly heal from sustained wounds.
Power Absorption: Delsin has the natural ability to absorb the abilities of other conduits, which he discovers after encountering a crashed conduit transport vehicle. This gives him the potential to be one of the most powerful Conduits ever in existence, due to the fact that he can have multiple powers at any point and can always absorb more.
Telepathic Perception: Delsin along with his ability to take the powers of others, also has the ability, through touch, to look at another person's past and the emotions they experienced to rapidly gain information of their lives. Although it's not confirmed, it appears that this power can't be used on non-Conduits because he has shown no signs of it when touching any non-Conduits such as his brother. This power is not to be confused with Telepathy, as he is not reading their minds, but receiving information.
Smoke Manipulation: Delsin's initial powers seem to be based on smoke and ember, having taken it from the Conduit he helped survive. He suddenly gains the capacity to shoot smoke out of his hands, or even turn into smoke and travel quickly around the city through the use of air ducts. He can also deploy smoke grenades, which, after explosion, cover affected enemies in smoke and incapacitate them. Delsin can use the chain on his arm as a whip, seemingly imbuing it with burning ash, similarly to how the Amp was wrought in Cole's electricity. Additionally, he can make use of a smoke dash ability for heightened motion and produce lateral propulsion for a short while via Smoke Thrusters. His smoke dash can also be used offensively, as he dashes through an enemy and rematerializes behind them, choke-slamming them to the ground in the process. Delsin also replenishes his power by absorbing smoke from chimneys, cars, and DUP tear gas canisters. He can use his special Smoke Karma Bomb abilty called Orbital Drop: Delsin dematerializes into three balls of smoke which propell upwards. Upon reaching a specific height, Delsin rematerializes and rapidly falls down, exploding into smoke and embers upon contact with the surface.
Neon Manipulation: Later on the game, Delsin absorbs from Abigail Walker the ability to control neon. With it, he is shown to have powers similar to his smoke dispersal abilities yet instead dissolves and reforms from gaseous energy based semblance. He can discharge Neon stream lasers from his hands, which also blow up upon contact to deal more damage to enemies than the smoke projectile as well as simulate some type of light dash, which when used dissolves him into Neon itself and enables him, and brief after images of him, to sprint up or around walls and literally run on air from a starting jump for brief periods of time. Delsin's chain can also be covered in neon and made rigid, allowing it to be used like in sword-like fashion; he can also use neon to charge it directly into enemies, knocking them over, similar to his smoke choke slam. He also has neon grenades which suspend enemies in air for a short amount of time. Aiming while using the Neon power set utilizes a mode similar to Precision, time slows down and it highlights certain weak points around specific enemy body parts. Weak points are Karma specific, shoot an enemy in the head to cause them to be "obliterated" and explode into a puff of red neon and receive evil karma, or shoot them in the shins to restrain the enemy to receive good karma. Sources show he also has some kind of propulsion ability honed by a force field situated at the lower legs similar to Cole's Static Thrusters and Delsin's own Smoke Thrusters. He can replenish his Neon reserves by absorbing it from the brightly lit neon signs situated around the city. With Neon power active, Delsin can use his special Neon Karma Bomb called Radiant Sweep: in which he concentrates neon energy into himself and then bursts, shooting beams in all directions, producing a massive explosion. The effects of which are currently unknown, other than the swathe of neon flames it leaves
Video Manipulation: Delsin then gains the ability of Video by absorbing a Conduit named Eugene Sims. Delsin can drain this power from television monitors to computer screen on satellite dishes. When using Video, Delsin can shoot out a stream of pixelated projectiles in a rapid fire motion similar to Cole’s Bolt Stream. Also gaining the ability to transform himself into faint pixels, becoming invisible to enemies for a certain time period. When using melee attacks, Delsin doesn’t seem to use his chain. Instead, depending on his karma, he creates a digital sword (good) or claws (evil) to hack and slash. Furthermore, when dashing he can create wings for himself to fly over obstacles and directly up walls. Dashing into satellite dishes will cause him to launch higher up in the air. Delsin can also mark and summon three Bloodthirsty Blades. When the blades are summoned, they then seek out the target that has been marked. With Video power active, Delsin can use his special Video Karma Bomb called Hellfire Swarm: in which he summons both angels and demons, from the game Heaven’s Hellfire, to swoop down and carpet bombing enemies. When over, the Karma Bomb will either subdue (good) or obliterate (evil) enemies depending on Delsin's decisions.
Concrete Manipulation: The last power Delsin gets, which is absorbed from Brooke Augustine, gaining her unique ability to manipulate Concrete. Delsin can drain this power from any down members of the D.U.P. he comes across. What also makes concrete separate itself from the other powers is that while using it, Delsin automatically takes less damage from enemy fire. While using the power he can shoot out a shrapnel of concrete in a burst fire manner. Delsin can also fire off slabs of concrete, very similar to one of Augustine attacks and those used by the weaponless DUP soldiers. Like Video, Delsin doesn’t seem to use the chain either when using concrete. Instead, Delsin smashes his hand on the ground, creating a miniature tremor that knocks enemies back. When dashing Delsin is covered in concrete wearing it like armor, making himself a living boulder. Delsin can also travel around using concrete thrusters, similar to Cole’s Static Thrusters, where stones are surrounded under him. Every time the thrusters are used, they initially lift him higher in the air, causing him to glide even farther. Surprisingly, out of all the current power sets (Smoke, Neon, Video and Concrete) Concrete is the only one that doesn’t have a Karma Bomb for some odd reason, this may be due to the Karma Bomb requiring another Blast Core Relay which he was unable to obtain. He can also use a miniature boost to push himself into the air which leaves no trace of damage from the launching point, unlike the DUP Knights' ability. When used while climbing a building Delsin will simply Launch himself vertically up it.
Parkour Skills: In addition, Delsin is physically able to climb up any kind of buildings, having the same free running and parkour abilities as Cole. He is described as not being a very experienced climber, but if he sees something he can climb, there's nothing stopping him from trying. Sucker Punch co-founder Chris Zimmerman has gone on record saying that Delsin can parkour two times faster than Cole.